At Finally Detached we fully understand the healing benefits of this sacred medicine. Here are some of the latest and most relevant research studies on the benefits of psilocybin for human health, categorized by their focus. Feel free to download the direct clinical trials tabel below. If your interested in a deep journey yourself then click here to book a call.
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Depression and Mental Health
- Treatment-Resistant Depression
- Study by Cleveland Clinic: Investigates psilocybin as a treatment for individuals with treatment-resistant depression. Participants receive psilocybin or placebo in a controlled setting. Early results indicate that psilocybin may be effective in treating depression when combined with psychological support (Cleveland Clinic).
- Johns Hopkins Study: Psilocybin treatment for major depression shows significant and durable improvements. Participants received two doses of psilocybin, leading to large decreases in depression severity sustained for up to a year (Home) (Home).
- Generalized Anxiety Disorder and Depression
- Johns Hopkins Research: This study highlights psilocybin's potential in alleviating anxiety and depression, particularly in patients with life-threatening cancer, showing substantial relief for up to six months after a single dose (Home).
- Emotional Processing and Neuroplasticity
- Evidence Review: Psilocybin disrupts the default mode network (DMN), which is typically overactive in depression, and promotes neuroplasticity. These changes may underlie the lasting improvements in mood and cognitive patterns observed following psilocybin treatment (MentalHealthDaily).
- Phase 3 Study of Psilocybin for Major Depressive Disorder (uAspire)
Location: Usona Institute
Description: A multicenter, randomized, double-blind study evaluating the efficacy, safety, and tolerability of psilocybin in adults with major depressive disorder, with a focus on treatment durability and long-term safety (Usona Institute).
History Of Psilocybin & Sacred Mushrooms (Mini Documentary)
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Addiction and Substance Use Disorders
- Alcohol Use Disorder
- Johns Hopkins Survey: An online survey of over 300 individuals with alcohol use disorder reported reduced or abstained alcohol use after taking psychedelics like psilocybin, suggesting further investigation into psychedelic-assisted treatment for alcoholism (Home).
- Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder
Location: University of Calgary
Description: Investigates the use of psilocybin-assisted psychotherapy in treating alcohol use disorder, focusing on its therapeutic benefits (Berkeley Psychedelics).
Chronic Pain Management
Chronic Low Back Pain
- UCSF Clinical Trial: This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Participants undergo a series of preparatory, dosing, and integration sessions (Clinical Trials at UCSF)
- Psilocybin for Cancer Pain: Location: Dana-Farber Cancer Institute, Belgium, and other locations Description: This clinical trial is investigating the use of psilocybin to alleviate opioid-refractory pain in patients with advanced cancer. The trial assesses the feasibility, safety, and preliminary efficacy of psilocybin-assisted therapy for managing severe cancer pain. Participants will receive a standardized dose of botanical psilocybin developed by Filament Health. Source: Filament Health (Filament Health).

finally_detached_psilocybin_clinical_trials.xlsx | |
File Size: | 13 kb |
File Type: | xlsx |
Cognitive and Emotional Shifts
- Psychedelic Experience and Brain Connectivity
- ScienceDaily Report: This study explores how psilocybin induces hyperconnectivity in the brain, linked to ego-modifying effects and profound changes in perception and emotion (ScienceDaily).
Specific Conditions and Mechanisms
- Body Dysmorphic Disorder
- Pilot Study: This study focused on individuals with body dysmorphic disorder resistant to traditional antidepressants. Over half of the participants responded positively to psilocybin therapy, with benefits lasting three months post-treatment (A Psychedelic Wellness Movement | YAWN).
- Cluster Headaches
- EEG Study: Participants with chronic cluster headaches showed reduced headache frequency after psilocybin treatment, suggesting psilocybin's potential in managing difficult-to-treat conditions (A Psychedelic Wellness Movement | YAWN).
- Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin
Description: This first-of-its-kind exploratory study, conducted by Yale School of Medicine, found that a single dose of psilocybin could reduce migraine frequency by 50% for at least two weeks. Participants experienced a significant reduction in both the frequency and intensity of migraine attacks. The trial involved ten migraine sufferers who participated in two sessions: one with a placebo and one with a moderate dose of psilocybin. Headache diaries were used to track the outcomes.
Location: Yale University

finally_detached_psilocybin_clinical_trials.xlsx | |
File Size: | 13 kb |
File Type: | xlsx |